https://journals.aiac.org.au/index.php/ABCMED/issue/feedAdvances in Bioscience and Clinical Medicine2023-04-11T08:05:29+10:00ABCMed Editorial Officeeditor.abcmed@aiac.org.auOpen Journal Systems<p><strong>Advances in Bioscience and Clinical Medicine (ABCmed)</strong> is an international open-access, peer-reviewed journal established in Australia. ABCmed spans all areas of bioscience and medicine publishing original research articles, review articles, short communications, case reports and correspondences. Both printed and online versions of ABCmed are available. The journal is indexed in leading indexing and abstracting services, including but not limited to NLM catalog, proquest, etc. Authors are encouraged to submit their manuscripts for review as there is no article submission and article processing charges. </p><table border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="417"><p><strong>ABCmed <strong>Highlights</strong></strong></p><ul><li><strong>Country of Publication: </strong>Australia <strong> </strong></li><li><strong>Publisher:</strong> <a href="http://www.aiac.org.au/" target="_blank">Australian International Academic Centre PTY.LTD.</a></li><li><strong><strong>Online </strong>ISSN:</strong> <a href="http://trove.nla.gov.au/work/186657819?selectedversion=NBD52153834" target="_blank">2203-1413</a></li><li><strong>Print ISBN:</strong> 9781291449501</li><li><strong><strong>Imprint</strong>:</strong> <a href="http://www.lulu.com/spotlight/AIAC" target="_blank">LuLu Press Inc.</a></li><li><strong>Acceptance Rate</strong>: <a href="/index.php/ABCMED/about/history">17% in 2020</a></li><li><strong>Frequency:</strong> Quarterly [2015 Onwards]</li><li><strong>Publication Dates:</strong> January, April, July, October </li><li><strong>Language:</strong> English</li><li><strong>Format:</strong> Print & Online</li><li><strong>Scope:</strong> Bioscience and Clinical Medicine </li><li><strong>Article Processing Charges: </strong><a href="/index.php/ABCMED/about/editorialPolicies#custom-2">No</a></li><li><strong>Open Access:</strong> Yes</li><li><strong>Refereed:</strong> Yes</li><li><strong>Abstracted:</strong> <a href="/index.php/ABCMED/about/editorialPolicies#custom-0">Yes</a></li><li><strong>Indexed:</strong> Yes</li><li><strong>Policy:</strong> <a href="/index.php/IJKSS/about/editorialPolicies#peerReviewProcess">Peer-reviewed</a></li><li><strong>Peer Review Time:</strong> Five to Six Weeks</li><li><strong>E-mail: </strong>editor.abcmed@aiac.org.au</li></ul></td><td valign="top" width="209"><p> <img src="/public/site/images/admin/vol_11.jpg" alt="" /></p></td></tr></tbody></table><div><br /><table border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="432"><p> <strong>Most Downloaded Articles</strong></p></td><td valign="top" width="432"><p> <strong>Most Cited Articles <em><strong>via Google Scholar</strong></em></strong></p></td></tr><tr><td valign="top" width="432"><ol><li>Management Of Post Stroke Seizures <em><em>Read 372 Times</em></em></li><li>The Effect of Cigarette Smoking on Blood Pressure and Hypertension <em><em>Read 170 Times</em></em></li><li>Rehabilitation Treatment In Dysarthria Caused By Stroke (Review) <em><em>Read 167 Times</em></em></li><li>Understanding D-Ribose and Mitochondrial Function <em><em>Read 161 Times</em></em></li><li>Comparison of interrater reliability and predictive validity of FOUR score and Glasgow Coma Scale in multi traumatic patients <em><em>Read 161 Times</em></em></li></ol></td><td valign="top" width="432"><ol><li>The effect of cigarette smoking on blood pressure and hypertension <em>Cited 16 Times</em></li><li>Facial soft tissue thickness in North-West of Iran <em>Cited 14 Times</em></li><li>Is ginger (Zingiber officinale) mouthwash a convenient therapeutic for denture stomatitis? <em>Cited 11 Times</em></li><li>Adhesion of streptococcus mutans to Zirconia, Titanium alloy and some other restorative materials:“An in-vitro study”<em> Cited 11 Times</em></li><li>The effect of biofeedback on the motor–muscular situation in rehabilitation of stroke patients: a randomized controlled trial <em>Cited 8 Times</em></li></ol><div> </div><span> Updated on 15 May 2021</span></td></tr></tbody></table></div>https://journals.aiac.org.au/index.php/ABCMED/article/view/7621A Study of BRCA1 Gene Exon 2 Mutation in Bangladeshi Female Breast Cancer Patients2023-03-25T02:44:43+11:00Jayasree Basujayasreetuli15@gmail.comZinnat Ara Yesminjayasreetuli15@gmail.comTaslima Hossainjayasreetuli15@gmail.comRayhan Shahrearjayasreetuli15@gmail.comBackground: Breast cancer is the most common malignancy and leading cause of death among women in Bangladesh. Mutations in BRCA genes increase the risk for breast cancer. A large number of distinct mutations and polymorphisms in the BRCA1 gene have been reported worldwide, a frameshift mutation in BRCA1 gene exon 2 (185delAG) is one of the commonly reported mutations. Therefore, the study was planned to determine the frequencies of mutation and polymorphisms in BRCA1 gene exon 2. Materials and Methods: A cross-sectional descriptive type of study was done on 100 adult Bengali Bangladeshi female patients with ductal carcinoma of breast of age range between 25 to 70 years by ‘selection checklist.’ Genomic DNA was isolated from the peripheral blood samples. Amplification of the desired sequence of BRCA1 exon 2 was checked in gel and then digested with restriction endonuclease enzyme (Hinfl). The fragments obtained were analyzed on a gel and photographed under UV light. Sanger sequencing was done on 10 blood samples for confirmation. Sequenced data was analyzed by Geneious Software version 11. Results: The onset of cancer was predominantly below 50 years and 44% of patients did not experience menopause as they developed cancer at a younger age. Gel photographs after enzyme digestion showed wild-type bands of 149bp in all samples. The chromatogram reveals wild-type sequence of exon 2 of BRCA1 gene. Conclusions: BRCA1 mutation status helps us in the cancer risk prediction, selection of therapeutic management and genetic counseling of the patients and families. Therefore, it is necessary to study the whole BRCA1 gene in our population.2022-10-31T00:00:00+11:00Copyright (c) 2023 Jayasree Basu, Zinnat Ara Yesmin, Taslima Hossain, Rayhan Shahrearhttps://journals.aiac.org.au/index.php/ABCMED/article/view/7622Raynaud’s Phenomenon as the Initial and Only Manifestation of Non-Hodgkin Lymphoma: A Case Report2023-03-25T02:44:43+11:00Gauri Parvathyaaka1376@gmail.comD.H.J.P.Uresha Lakshaniaaka1376@gmail.comAsadullah Khanaaka1376@gmail.comAakansh Maheshwariaaka1376@gmail.comKaivan Patelaaka1376@gmail.comRaynaud’s phenomenon is one of the commonest manifestations of rheumatic diseases. However, it can be caused by non-Rheumatic conditions as well. Among non-rheumatic causes, cancers are widely reported as the culprit”. Raynaud’s phenomenon caused by non-rheumatic diseases are commonly resistant to standard treatment options They are associated with more severe infections. Among non-rheumatic causes, cancers are widely reported as the culprit. We present a case of non-Hodgkin lymphoma presenting solely with Raynaud’s phenomenon.2022-10-31T00:00:00+11:00Copyright (c) 2023 Gauri Parvathy, D.H.J.P.Uresha Lakshani, Asadullah Khan, Aakansh Maheshwari, Kaivan Patelhttps://journals.aiac.org.au/index.php/ABCMED/article/view/7623Trick or Treat: Curative Management of Esophageal Squamous Cell Carcinoma of a COVID-positive Patient2023-03-25T02:44:43+11:00Saqib Raza Khansaqib.raza31@yahoo.comSaad Nasirsaqib.raza31@yahoo.comMuhammad Nauman Zahirsaqib.raza31@yahoo.comYasmin Abdul Rashidsaqib.raza31@yahoo.comThe novel coronavirus pneumonia COVID-19 which is reportedly caused by SARS-CoV-2 infection can potentially lead to a course of clinical symptoms and fatal illnesses. Reported first in 2019, it has now affected more than 596,873,121 people, worldwide. In addition to its clinical manifestation in humans, the COVID-19 virus in cancer patients is significantly declining a positive prognosis. In the time of an ongoing global pandemic, oncologists are struggling to provide appropriate care to cancer patients due to their increased susceptibility to severe complications of COVID-19 which can be attributed to their immunosuppressed status caused by the malignancy and anticancer treatments. Similarly, the lack of literature, evidence, and consensus on whether to give antineoplastic agents to patients with active COVID-19 infection pose a unique challenge for physicians. In this article, we present a case of a 47-year-old female who was diagnosed with squamous cell carcinoma of the esophagus and later tested positive for SARS-CoV-2. Under unanimous decision, oncological treatment for the malignancy was initiated with a combination of chemotherapy and radiation without a consequential delay as per multidisciplinary tumor board (MDT) meeting decision which results in clinical improvement.2022-10-31T00:00:00+11:00Copyright (c) 2023 Saqib Raza Khan, Saad Nasir, Muhammad Nauman Zahir, Yasmin Abdul Rashidhttps://journals.aiac.org.au/index.php/ABCMED/article/view/7624A Rare and Underestimated, However, A Treatable Disease: Tarlov Cyst and Adhesive Arachnoiditis2023-04-11T08:05:29+10:00Lidia Sarnatarolidiasarnataro@gmail.comTarlov cyst (TCs) is also called perineural cyst, which is a rare disease of the posterior nerve root prevalently localized in the lumbo-sacral region, however, it is also possible in every part of the spinal cord. These cysts represent a dilation of the nerve-root sheath that often communicate with subarachnoid space through a valve-like mechanism containing cerebrospinal fluid (CSF) and neural tissue. Tarlov cyst is often asymptomatic and discovered incidentally in the MRI, however, sometimes it can be symptomatic and is characterized by many symptoms, such as low back pain, sacral radiculopathy, sciatica, coccydynia or cauda equina syndrome, constipation, dyspareunia, urinary incontinence, and retention as well as blurry vision and headache. Moreover, these cysts can be a cause of CSF leak and therefore culprit of idiopathic intracranial hypotension. The etiopathogenesis is still unclear, but it is documented that a trauma, an old hemorrhage, and congenital and iatrogenic causes may be responsible for it. Association between the Tarlov cysts and the arachnoiditis have been studied in the last years. Tarlov cyst appears to be a consequence of the arachnoiditis. In general, there are four stages of arachnoiditis. In the last stage, it is possible that some patients cannot walk anymore becoming wheelchair bound. Moreover, arachnoiditis is often associated to type I ACM, syringomyelia and Ehlers-Danlos syndromes. Although Tarlov cyst has been known since 1938, the year in which Dr. Isador Max Tarlov described it first as an incidental finding in cadavers, nowadays many doctors do not really know this disease and underestimate it by thinking that it cannot be responsible for the above listed symptoms. The main aim of this work is to educate the medical community to consider Tarlov cyst in the differential diagnosis of back pain patients, and in other diseases. While the surgery represents the most effective therapy for such patients, a treatment of the arachnoiditis with the stem cells therapy should be also considered.2022-10-31T00:00:00+11:00Copyright (c) 2023 Lidia Sarnataro