Cerebellopontine angle metastatic melanoma mimicking schwannoma in a sexagenarian: Case report

Hui-Min Xie, Li Li, Seidu A. Richard, Zhigang Lan, Yuekang Zhang

Abstract


Introduction: Metastasis of melanomas to the cerebellopontine angle (CPA) are very rare. Dissemination via blood, cerebrospinal fluid and/or leptomeninges may be the principal pathway for metastatic spread of malignant melanomas to the CPA. Case presentation: A 68-years old man presented with two years history of hearing lost in the right ear with associated dizziness and headaches. A skin lesion was seen on the patient’s right forearm. MRI revealed a nodular abnormal signal intensity at the right CPA which was resected and pathology revealed metastatic melanoma. Conclusion: Aggressive treatment regime comprising of a combination of surgery, chemotherapy and radiotherapy is very efficacious in prolonging the survival of patients with metastatic melanomas to the brain especially the metastasis to the CPA.

Keywords


CPA, Melanoma, Metastasis, Schwannoma, Surgery, Skin

Full Text:

PDF

References


Arriaga MA, Lo WW, Brackmann DE. Metastatic melanoma to the cerebellopontine angle. Clinical and imaging characteristics. Arch Otolaryngol Head Neck Surg 1995;121(9):1052-1056.

Bafaloukos D, Gogas H. The treatment of brain metastases in melanoma patients. Cancer Treat Rev 2004;30(6):515-520.

Becco P, Gallo S, Poletto S, Frascione MPM, Crotto L, Zaccagna A, et al. Melanoma Brain Metastases in the Era of Target Therapies: An Overview. Cancers 2020;12(6).

Brackmann DE, Doherty JK. CPA melanoma: diagnosis and management. Otol Neurotol 2007;28(4):529-537.

Escott EJ. A variety of appearances of malignant melanoma in the head: a review. Radiographics 2001;21(3):625-639.

Fernandez E, Maira G, Puca A, Vignati A. Multiple intracranial metastases of malignant melanoma with long-term survival. Case report. J Neurosurg 1984;60(3):621-624.

Gerganov VM, Hore N, Herold C, Wrede K, Stan AC, Samii A, et al. Bilateral malignant melanoma metastases to the internal auditory canal/cerebellopontine angle: surgical management and preservation of function. J Neurosurg 2008;108(4):803-807.

González Cao M, Malvehy J, Martí R, Conill C, Sánchez M, Martín M, et al. Biochemotherapy with temozolomide, cisplatin, vinblastine, subcutaneous interleukin-2 and interferon-alpha in patients with metastatic melanoma. Melanoma Res 2006;16(1):59-64.

Guzel A, Maciaczyk J, Dohmen-Scheufler H, Senturk S, Volk B, Ostertag CB, et al. Multiple intracranial melanoma metastases: case report and review of the literature. J Neurooncol 2009;93(3):413-420.

Hofmann M, Kiecker F, Wurm R, Schlenger L, Budach V, Sterry W, et al. Temozolomide with or without radiotherapy in melanoma with unresectable brain metastases. J Neurooncol 2006;76(1):59-64.

Kingdom TT, Lalwani AK, Pitts LH. Isolated metastatic melanoma of the cerebellopontine angle: case report. Neurosurgery 1993;33(1):142-144.

Lade-Keller J, Yuusufi S, Riber-Hansen R, Steiniche T, Stougaard M. Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma. Melanoma Res 2018;28(5):398-409.

Mastorakos P, Xu Z, Yu J, Hess J, Qian J, Chatrath A, et al. BRAF V600 Mutation and BRAF Kinase Inhibitors in Conjunction With Stereotactic Radiosurgery for Intracranial Melanoma Metastases: A Multicenter Retrospective Study. Neurosurgery 2019;84(4):868-880.

Meier S, Baumert BG, Maier T, Wellis G, Burg G, Seifert B, et al. Survival and prognostic factors in patients with brain metastases from malignant melanoma. Onkologie 2004;27(2):145-149.

Panagiotou IE, Brountzos EN, Kelekis DA, Papathanasiou MA, Bafaloukos DI. Cerebral metastases of malignant melanoma: contemporary treatment modalities and survival outcome. Neoplasma 2005;52(2):150-158.

Tu AS, Wang H, Harris-McCorkle L, Saunders JR, Jr. Bilateral involvement of the cerebellopontine angles by malignant melanoma metastasis: a case report. Md Med J 1994;43(11):967-970.

van Wiltenburg R, Sevick RJ, Clark AW, Burger PC, LeBlanc FE. Choroidal melanoma metastasis as a rare cause of cerebellopontine angle lesion: 2 case reports. Can Assoc Radiol J 1998;49(3):185-189.

Yuh WT, Mayr-Yuh NA, Koci TM, Simon JH, Nelson KL, Zyroff J, et al. Metastatic lesions involving the cerebellopontine angle. AJNR American journal of neuroradiology 1993;14(1):99-106.




DOI: https://doi.org/10.7575/aiac.abcmed.v.10n.1p.33

Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

2013-2022 (CC-BY) Australian International Academic Centre PTY.LTD.

Advances in Bioscience and Clinical Medicine