Rosa canina as an adjunctive treatment of asthma: A hypothesis

Samin Hamidi, Haleh Vaez, Parina Asgharian


Asthma is one of the most common chronic disorders and about 7% of the US population suffers from asthma. Initial response to allergy is associated with mediators like histamine, prostaglandin (PG) D2 and leukotriene (LT) C4. In asthmatic patients, 5-lipo-oxygenase (5-LO) pathway produces more LTC4 than the healthy people. Also, pro-inflammatory factors like interleukin (IL)-1, IL-6 and Tumor Necrosis Factor (TNF)-α play a remarkable role in bronchoconstriction. The common asthma medications are associated with a number of unwanted side effects, especially throughout long term treatment. Herbal medication is an alternative treatment for asthma and the plants are rich sources of antioxidants that intensively reduce the activity of free radicals. Among several herbs, Rosa canina (RC) is a potent anti-inflammatory remedy which contains a number of well-known antioxidants including vitamin C, quercetin, hesperidin, rutin and some other therapeutic compounds. The aim of this study was to review the scientific evidences supporting the probable influence of Rosa canina on asthma.

Keywords: Asthma; Rosa canina; Anti-inflammatory

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Haas LF. Rosa canina (dog rose). J Neurol Neurosurg Psychiatry 1995;59(5):470.

Chrubasik C, Roufogalis BD, Muller-Ladner U, Chrubasik S. A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res 2008;22(6):725-733.

Altiner D, Kilicgun H. Correlation between antioxidant effect mechanisms and polyphenol content of Rosa canina. Phcog Mag 2010;6:238-241.

Kharazmi A, Winther K. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology 1999;7(4):377-386.

Deliorman Orhan D, Hartevioğlu A, Küpeli E, Yesilada E. In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits. J. Ethnopharmacol 2007;112(2):394-400.

Kupeli E, Orhan I, Toker G, Yesilada E. Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. J. Ethnopharmacol 2006;107(2):169-174.

Wenziga E.M, Widowitza U, Kunertb O, Chrubasikc S, Bucara F, Knaudera E, Bauer R. Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations. Phytomedicine 2008;15(10):826-835.

Schunemann H.J, McCann S, Grant B.J.B, Trevisan M, Muti P, Freudenheim J.L. Lung function in relation to intake of carotenoids and other antioxidant vitamins in a population-based study. Am J Epidemiol 2002;155(5):463-471.

Meren M, Pruljan L.J, Loit H.M, Polluste J, Jonsson E, Kiviloog J, Lundback B. Asthma, chronic bronchitis and respiratory symptoms among adults in Estonia according to a postal questionnaire. Respiratory Medicine 2001;95(12):954-964.

Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999;54(9):825-857.

Batra J, Singh T.P, Mabalirajan U, Sinha A, Prasad R, Ghosh B. Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Thorax 2007;62(1):16-22.

Min J.K, Kim Y.M, Kim Y.M, Kim E.C, Gho Y.S, Kang I.J, Lee S.Y, Kong Y.Y, Kwon Y.Gl. Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand. J Biol Chem 2003;278(41):39548-39557.

Lee KS. An antioxidant modulates expression of receptor activator of NF-kappaB in asthma. Exp Mol Med. 2006;38(3):217-229.

Singh B.B, Khorsan R, Vinjamury S.P, Der-Martirosian C, Kizhakkeveettil A, Anderson T. Herbal treatments of asthma: a systematic review. J Asthma 2007;44(9):685-698.

Srivastava K.D, Kattan J.D, Zou Z.M, Li J.H, Zhang L, Wallenstein S, Goldfarb J, Sampson H-A, Li X.M. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. Journal of allergy and clinical immunology(JACI). 2005;115(1):171-178.

Hodisan T, Socaciu C, Ropan I, Neamtu G. Carotenoid composition of Rosa canina fruits determined by thin-layer chromatography and high-performance liquid chromatography. J Pharm Biomed Anal 1997;16(3):521-528.

Reifen R, Nur T, Matas Z, Halpern Z. Lycopene supplementation attenuates the inflammatory status of colitis in a rat model. Int J Vitam Nutr Res 2001;71(6):347-351.

Wood LG, Gibson PG, Garg ML. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 2003;21(1):177-186.

dard, P., Damon M, Cluzel M, Bousquet J, Chanez P, Crastes De Paulet A, Michel F-B.

Godard P, Damon M, Cluzel M, Bousquet J, Chanez P, Crastes De Paulet A, Michel F-B. Oxygen free radicals and bronchial asthma. Allerg Immunol (Paris) 1987;19(8 ):15-18.

Rahman I, Morrison D, Donaldson K, MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 1996;154(4 Pt 1):1055-1060.

Neuman I, Nahum H, Ben-Amotz A. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy 2000;55(12):1184-1189.

Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radic Res 2008;42(1):94-102.

Bagchi D, Garg A, Krohn R.L, Bagchi M, Tran M.X, Stohs S.J. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 1997;95(2):179-189.

Zhou D.y, Du Q, Li R.R, Huang M, Zhang Q, Wei G.Z. Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase. Planta medica 2011;77(14):1575-1581.

Fitzpatrick AM, Jones DP, Brown LA. Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2012;17(2):375-408.

Li WG, Zhang XY, Wu YJ, Tian X. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol Sin 2001;22(12):1117-1120.

Hosseini S, Pishnamazi S, Sadrzadeh S.M.H, Faridi F, Farid R, Watson R.R Pycnogenol (R) in the Management of Asthma. J Med Food 2001;4(4):201-209.

Cholbi MR, Paya M, Alcaraz MJ. Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation. Experientia 1991;47(2):195-199.

Shakibaei M, Allaway D, Nebrich S, Mobasheri A. Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1beta-Induced NF-kappaB Activation in Canine Articular Chondrocytes. Evid Based Complement Alternat Med 2012;2012:509383.

Larsen E, Kharazmi A, Christensen LP, Christensen SB. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 2003;66(7):994-995.

Chung KF. Drugs to suppress cough. Expert Opin Investig Drugs 2005;14(1):19-27.

Chi Y.S, Jonga H.G, Sonb K.H, changc H.W, Kangd S.S, Kima H.P. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem Pharmacol 2001;62(9):1185-1191.

Nair M.P, Mahajan S, Reynolds J.L, Aalinkeel R, Nair H, Schwartz S.A, Kandaswami C. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol 2006;13(3):319-32.


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