Evaluation of Laxative Activity of Vaishvanara Churna: An Ayurvedic Formulation

Bagepalli Srinivas Ashok Kumar, Gopisetty Saran, Ramachandra Harshada, Kupphalli Narayanswamy Bharath, Arun Kumar, Kruba Sreeramulu Kulasekar

Abstract


Vaishvanara churna is an Ayurvedic formulation traditionally used as laxative, analgesic, anti-inflammatory and arthritic agent. Since there was no scientific proof of this formulation as laxative, we aimed to screen the laxative activity of Vaishvanara churna in rats. Rats were divided into 4 groups, 6 animals each. First group acted as control, second group as standard (Senna, 30 mg/kg) and third and fourth groups received aqueous extract of Vaishvanara churna at doses 100 and 200 mg/kg, respectively. Compared with the control group, aqueous extract of Vaishvanara churna at 100 mg/kg did not lead to a statistically significant increase in 8th-h fecal output; however, 16th-h output was significantly increased (p<0.01). Vaishvanara churna at 200 mg/kg significantly increased the fecal output of rats (p<0.01) compared with that of the control group both at 8th and 16th hours. Our investigation showed that Vaishvanara churna may possess potent laxative activity.

 

Keywords: Vaishvanara churna, laxative activity, Senna


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References


Muller-Lissner S. The patholophysiology, diagnosis and treatment of constipation. Dtsch Artztebl Int. 2009;106:424-432.

Schiller LR. Review article: the therapy of constipation. Aliment Pharmacol Ther. 2001;15(6):749-763.

Di Gregorio C, Losi L, Fante R, Modica S, Ghidoni M, Pedroni M, Tamassia MG, Gafà L, Ponz de Leon M, Roncucci L. Histology of aberrant crypt foci in the human colon. Histopathology. 1997;30(4):328-334.

Johanson JF. Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007;25:599-608.

The Ayurvedic Pharmacopoeia of India. Part I, Vol. IV. New Delhi: Government of India, Ministry of Health & Family Welfare, Department of AYUSH; 2007. p. 57-58.

Capasso F, Mascolo N, Autore G, Romano V: Laxatives and the production of autacoids by rat colon. J Pharm Pharmacol. 1986;38:627-629.

Saindhava Lavana – Rock Salt Benefits, Ayurveda Usage, Side Effects. http://easyayurveda.com/2013/09/27/saindhava-lavana-rock-salt-benefits-ayurveda-usage-side-effects/ (accessed February 06, 2014).

Khare CP. Indian Medicinal Plants. Berlin: Springer Verlag; 2007. p. 665-666.

Kirtikar KR, Basu BD. Indian Medicinal Plants. Dehra Dun: International Book Distribution; 2006. p.1565-1567.

Nadkarni KM. Indian Materia Medica. Bombay: Bombay Popular Prakashan; 2007. p. 80-83.

Malhotra S, Singh AP. Medicinal properties of ginger (Zingiber officinale Rosc.). Nat Prod Rad. 2003; 2(6):296-301.

Ballabh B, Chaurasia OP, Ahmed Z, Singh SB. Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders. J Ethnopharmacol. 2008; 118(2):331-339.

Lee HS, Won NH, Kim KH, Lee H, Jun W, Lee KW. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull. 2005; 28(9):1639-1644.


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