Correlation of Erythrocyte Trans Fatty Acids with Ovulatory Disorder Infertility in Polycystic Ovarian Syndrome

Aisa Ghaffarzad, Reza Amani, Masoud Darabi, Amir Ghaffarzad, Mahzad Mehrzad Sadaghiani, Bahman Cheraghian

Abstract


Trans fatty acids are considered to be the important modifiable factor of the ovulatory infertility disorder. The purpose of this study was to test the hypothesis that higher trans fatty acids of erythrocytes (RBC) are associated with the risk of ovulatory infertility disorder in polycystic ovarian syndrome (PCOS).

Thirty five infertile women with polycystic ovarian syndrome, defined by AES criteria and 29 age-matched healthy women as a control group were recruited for the study. After physical measurements and nutritional assessment, blood samples were collected. Fasting serum glucose and insulin were measured, and then insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Erythrocyte fatty acids were measured by gas chromatography.

The patients group had higher waist circumference (WC), insulin levels, HOMA-IR than controls (p< 0.05). Also, case group had lower percentage of normal BMI (BMI<25), physical activity and education levels than healthy women (p< 0.05). Among RBC trans fatty acids only trans linoleate (18:2t) were significantly higher in case group than control women (p= 0.019). PCOS group tended to consume more food rich in TFAs than the control group. Logistic regression analysis also showed that only 18:2t is positively associated with risk of ovulatory disorder infertility in PCOS (OR= 1.225, 95% CI. 1.024-1.465; P= 0.026), which was not affected after adjustment for BMI, physical activity and education levels.

The results suggested that RBC trans fatty acids might be a predictor of increased risk for ovulatory infertility disorder in women with PCOS.


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References


Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertility and sterility. 2009;92(5):1520-4.

Balen AH, Rutherford AJ. Managing anovulatory infertility and polycystic ovary syndrome. BMJ: British Medical Journal. 2007;335(7621):663.

Fauser B. PCOS: treatment of infertility and prediction of success. 2011.

Hernandez MI, Mericq V. Polycystic ovarian syndrome. Brook's Clinical Pediatric Endocrinology, Sixth Edition. 2009:559-70.

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. Journal of Clinical Endocrinology & Metabolism. 2004;89(6):2745-9.

March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Human reproduction. 2010;25(2):544-51.

Kumarapeli V, Seneviratne RdA, Wijeyaratne C, Yapa R, Dodampahala S. A simple screening approach for assessing community prevalence and phenotype of polycystic ovary syndrome in a semiurban population in Sri Lanka. American journal of epidemiology. 2008;168(3):321-8.

Tehrani FR, Simbar M, Tohidi M, Hosseinpanah F, Azizi F. The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study. Reprod Biol Endocrinol. 2011;9:39.

Heitman E. Infertility as a public health problem: why assisted reproductive technologies are not the answer. Stan L & Pol'y Rev. 1994;6:89.

O'Connor A, Gibney J, Roche HM. Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet. Proceedings of the Nutrition Society. 2010;69(4):628.

Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. New England Journal of Medicine. 2006;354(15):1601-13.

Mozaffarian D, Abdollahi M, Campos H, Houshiarrad A, Willett W. Consumption of trans fats and estimated effects on coronary heart disease in Iran. European Journal of Clinical Nutrition. 2007;61(8):1004-10.

Esmaillzadeh A, Azadbakht L. Consumption of hydrogenated versus nonhydrogenated vegetable oils and risk of insulin resistance and the metabolic syndrome among Iranian adult women. Diabetes care. 2008;31(2):223-6.

Ghahremanpour F, Firoozrai M, Darabi M, Zavarei A, Mohebbi A. Adipose tissue trans fatty acids and risk of coronary artery disease: a case-control study. Annals of Nutrition and Metabolism. 2008;52(1):24-8.

Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Dietary fatty acid intakes and the risk of ovulatory infertility. The American journal of clinical nutrition. 2007 Jan;85(1):231-7. PubMed PMID: 17209201. Epub 2007/01/09.

Yu D, Sun Q, Ye X, Pan A, Zong G, Zhou Y, et al. Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals. Diabetologia. 2012;55(11):2954-62.

Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. The American journal of clinical nutrition. 2007;86(1):74-81.

Baylin A, Kim MK, Donovan-Palmer A, Siles X, Dougherty L, Tocco P, et al. Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: comparison with adipose tissue and plasma. American journal of epidemiology. 2005;162(4):373-81.

Initiative NOE. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: National Heart, Lung, and Blood Institute; 1998.

Esmaillzadeh A, Azadbakht L. Major dietary patterns in relation to general obesity and central adiposity among Iranian women. The Journal of nutrition. 2008;138(2):358-63.

Wheeler ML, Daly A, Evert A, Franz MJ, Geil P, Holzmeister LA, et al. Choose Your Foods: Exchange Lists for Diabetes, 2008: Description and Guidelines for Use. Journal of the American Dietetic Association. 2008;108(5):883-8.

Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.

Bligh E. Extraction of lipids in solution by the method of Bligh & Dyer. Can J Biochem Physiol. 1959;37(8):911-7.

Lepage G, Roy C. Direct transesterification of all classes of lipids in a one-step reaction. Journal of Lipid Research. 1986;27(1):114-20.

Douglas CC, Norris LE, Oster RA, Darnell BE, Azziz R, Gower BA. Difference in dietary intake between women with polycystic ovary syndrome and healthy controls. Fertility and sterility. 2006;86(2):411-7.

Toledo E, Lopez-del Burgo C, Ruiz-Zambrana A, Donazar M, Navarro-Blasco Í, Martínez-González MA, et al. Dietary patterns and difficulty conceiving: a nested case–control study. Fertility and sterility. 2011;96(5):1149-53.

Mozaffarian D, Aro A, Willett W. Health effects of trans-fatty acids: experimental and observational evidence. European Journal of Clinical Nutrition. 2009;63:S5-S21.

Saravanan N, Haseeb A, Ehtesham NZ. Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. European Journal of Endocrinology. 2005;153(1):159-65.

Angelucci A, Garofalo S, Speca S, Bovadilla A, Gravina GL, Muzi P, et al. Arachidonic acid modulates the crosstalk between prostate carcinoma and bone stromal cells. Endocrine-related cancer. 2008;15(1):91-100.

Bender K, Walsh S, Evans AC, Fair T, Brennan L. Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. Reproduction. 2010;139(6):1047-55.

Baylin A, Kabagambe EK, Siles X, Campos H. Adipose tissue biomarkers of fatty acid intake. The American journal of clinical nutrition. 2002;76(4):750-7.

Arab L. Biomarkers of fat and fatty acid intake. The Journal of nutrition. 2003;133(3):925S-32S.


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