The Pivotal Novel Pathogenic Roles of Hyaluronic Acid and its Receptors in Gliomas

Seidu A. Richard, Nii Korley Kortei, Sylvanus Kampo


HA/CD44 as well as HA/RHAMM cross-talks resulted in glioma cell adhesion, mechanosensing, as well as invasive motility. RHAMM was overexpressed in DIPG and may contribute to the diffuse growth pattern and invasion in DIPG just like other forms of gliomas other than CD44. BEHAB/brevican could be a potential biomarker for glioma detection as well as its progression or malignancy.


CD44, DIPG, Hyaluronan, Glioma, Glioblastoma, RHAMM

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