Castleman Disease in the Buccal Space Mimicking Lymphoma: A Case Report

Mohsen Hashemi, Javad Yazdani, Amir Hossein Bani Shah Abadi, Tannaz Abdollah Zade Baghai, Behrouz Shokouhi


Castleman disease is a benign lymphoproliferative disorder of unknown etiology, more commonly appearing in the mediastinum. Craniofacial involvement is rare. Surgical excision is the only intervention needed for the unicentric type, while systemic treatment would be necessary for the multicentric type. Here, we report a rare case of unicentric castleman disease of the buccal space of a 23-year-old woman. Additionally, we review the radiological and histopathological features of this lesion.


Castleman Disease, Lymphoproliferative Disorders, Buccal Space

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Casper C. The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol. 2005;129(1):3-17.

Jhan JH, Li CC, Wu WJ, Lee HY. Isolated retroperitoneal Castleman's disease: A case report and literature review. Clinical Case Reports.

Munshi N, Mehra M, van de Velde H, Desai A, Potluri R, Vermeulen J. Use of a claims database to characterize and estimate the incidence rate for Castleman disease. Leuk Lymphoma. 2015;56(5):1252-60.

Leger-Ravet M, Peuchmaur M, Devergne O, Audouin J, Raphael M, Van Damme J, et al. Interleukin-6 gene expression in Castleman's disease. Blood. 1991;78(11):2923-30.

Talat N, Belgaumkar AP, Schulte K-M. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012;255(4):677-84.

Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, et al. POEMS syndrome: definitions and long-term outcome: Presented in abstract form at the 41st annual meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999. Blood. 2003;101(7):2496-506.

Keller AR, Hochholzer L, Castleman B. Hyaline‐vascular and plasma‐cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972;29(3):670-83.



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