Compare the Effects of Epinephrine and Vasopressin in Return of Spontaneous Circulation

Samad Shams Vahdati, Azra Nejabatian, Farzad Rahmani, Paria Habibollahi, Pegah Sepehri Majd


Background: There is a conflict in the superiority of each of the vasopressin and epinephrine compared to the other. Vasopressin has a vasoconstrictive action that results in an increase of the coronary perfusion pressure. Due to the expensive and sometimes scarce of vasopressin in most hospitals, this study aims to evaluate the response rate of vasopressin compared with epinephrine, in return of ROSC. Methods: In this descriptive-analytical study all patients in the emergency medicine department were enrolled in the study suffered a cardiopulmonary arrest and resuscitation will be done instantly for them (According to the guidelines AHA 2010). Their data were extracted from the hospital records and the success rate of recovery, 3-month survival and complications in patients recovering from the drug used during the CPR were analyzed. Results: A total of 61 patients record were analyzed. 31 patients had received epinephrine alone and 30 patients received a combination of epinephrine and vasopressin. No significant difference was observed between the two groups in terms of sex, sepsis, hypovolemia, renal failure, cancers, drug toxicity, brady, dysrhythmia, PEA, VT, VF, defibrillator, duration of CPR and three month outcome. The mean time of CPR in combination of epinephrine and vasopressin group was 27.26±12.72 and the mean time of CPR in epinephrine group was 27.24±13.510 (p-value= 0.99).Conclusion: Among patients with in-hospital cardiopulmonary arrest in this study no statistically significant difference was obtained between the results of treatment with epinephrine alone and combination of epinephrine and vasopressin.


Cardiopulmonary Resuscitation (CPR), Return of Spontaneous Circulation (ROSC), Epinephrine, Vasopressin

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