Thyroid Function as a Predictive Tool for The Prognosis of Traumatic Patients Admitted in Surgery ICUs

Ramin Azhough, Reza Movassaghi, Ali Farbod

Abstract


Background: APACHE Score is an important criterion for determining the patient prognosis, especially in critically ill patients. According to significantly changes in the serum levels of thyroidal hormones in patients, especially in critically ill patients, the aim of the present study was to evaluate the relationship between thyroid function and APACHE 4 score in the prognosis of the traumatic patients admitted in surgery ICU. Method & Material: In a descriptive-analytical study, 90 patients with multiple trauma were studied. Thyroid hormones and APACHE 4 Score were evaluated on 1st, 5th and10th days of admission for each patient. Their clinical features and duration of hospitalization, either in trauma unit or ICU, elation between thyroidal hormones and APACHE 4 Score, duration of hospitalization, and survival of patients were evaluated. Results: This study included 90 patients. A statistically significant relation was detected between thyroid hormones (TT3) and APACHE 4 Score and duration of hospitalization. Conclusion: TT3 might be utilized as a prognostic factor in the traumatic patients admitted to ICU.

 


Keywords


Trauma; Thyroid; ICU; APACHE

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References


Civetta JM. Prediction and definition of outcome. (1997). In: Civetta JM, Taylor RW, Kirby RR (ed) Critical care. Lippincott-Raven, Philadelphia, 24,127–147

Keegan MT, Gajic O, Afessa B. (2012). Comparison of APACHE III, APACHE IV, SAPS 3, and MPM0III and Influence of Resuscitation Status on Model Performance Comparison of ICU Prognostic Models. CHEST Journ l, 142(4),851-858.

Plank LD, Connolly AB, Hill GL. (1998). Sequential changes in the metabolic response in severely septic patients during the first 23 days after onset of peritonitis. Ann Surg, 228,146-158.

Fong Y, Marono MA, Moldawer LL, et al.(1990). The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest, 85,1896-1904.

Zaloga, G. P., Chernow, B. A. R. T., Smallridge, R. C., Zajtchuk, R. U. S. S. E. L. L., Hall-Boyer, K. A. T. H. R. Y. N., Hargraves, R. O. N. A. L. D., ... & Burman, K. D. (1985). A longitudinal evaluation of thyroid function in critically ill surgical patients. Annals of surgery, 201(4),456.

KAPTEIN EM. (1986). Thyroid hormone metabolism in illness. In: HENNEMANGN, ed. Thyroid hormone metabolism New York Marcel Dekker, 25,297-333.

Akbari, G. Akhavan, and A. Mohammadian. (2012). Comparison of the RTS and ISS scores on prediction of survival chances in multiple trauma patients. Injury, 6,11.

Van der Berge G, de Zegher F, Boullion R. (1998). Acute and prolonged critical illness as differed neuroendocrine paradigms. J Clin Endocrine Metab, 83,1827-1834.

Jarek MJ, Legare EJ, McDermott MT, et al. (1993). Endocrine profiles for outcome prediction from the intensive care unit. Crit Care Med, 21,543-550.

Wade CE, Lindberg JS, Cockrell JL, Lamiell JM, et al. (1998). Upon-admission adrenal steroidogenesis is adapted to degree of illness in intensive care unit patients. J Clin Endocrinal Metab, 67,223-227.

Nierman DM, Mechanick JL. (1999). Hypotesteronemia in chronically critically ill men. Crit Care Med, 27,2418-2421.

Christeff N, Carli A, Benassayag C, et al. (1992). Relationship between changes in serum estrone levels and outcome in human males with septic shock. Circ Shock, 36,249-255.

Ray DC, Macduff A, Drummond GB, et al. (2002). Endocrine measurements in survivors and non- survivors from critical illness. Intensive Care Med, 28,1301-1308.

Rothwell PM, Udwadia ZF, Lawler PG. (1993). Thyrotyropin concentration predicts outcome in critical illness. Anaesthesia, 48,373-376.

Slag MF, morley JE, Elson MK, et al. (1981). Hypothyroxinemia in critically ill patients as a predictor pf high mortality. JAMA, 245,34-45.




DOI: http://dx.doi.org/10.7575/aiac.abcmed.17.05.03.04

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