Prognosis of the Newborns with Congenital Heart Diseases

Akbar Molaei, Gholamreza Asadi, Maryam Khoshbakht


Background: Congenital heart disease (CHD) is defined as problems affecting the heart of the fetus. According to previous studies, the incidence rate varies from 4-12 in 1000 live births. This study aimed to evaluate the demographic characteristics, clinical presentations, and findings that have impact on the prognosis of newborns hospitalized in Tabriz children Hospital, northwest of Iran. Methods: This cross-sectional study was conducted on 82 neonates with CHD admitted in Tabriz children Hospital, northwest of Iran from December 2011 to December 2012. Demographic characteristics, main complaints, symptoms, clinical presentations, associated anomalies, diagnoses, and also the correlation between the treatment process and mortality were evaluated. All data were analyzed using SPSS™ version 16 statistical software. Results: A total of 82 neonates with CHD were enrolled. The mean age and birth weight were 8.54 days and 2828.17 grams, respectively. The most common chief complaint was respiratory distress (58 cases, 70.73%). The most common diagnosis was d-transposition of great arteries and the most frequent therapeutic procedure was medical therapy in combination with mechanical ventilation (31 cases, 37.8%). 10 neonates (12.1%) had complications while seizure was the most common complication of the study (4 case, 4.87%). Of 82 newborns in this study, 30 patients (36.6%) died of which 13 cases (43.33%) had DTGA; the most common therapeutic procedure was mechanical ventilation plus medical therapy which was performed in 22 patients (73.33%). In our study, no significant correlation could be observed between age, sex or weight of neonates and final outcome.

Conclusion: Mortality of neonates with critical CHD is high. Also, the neonates treated with more invasive methods have higher mortality rates. It is obvious that both early detection and timely management affect ultimate prognosis of these patients. Hence, prenatal (fetal echocardiography) and postnatal (pulse oximetry and echocardiography) diagnostic evaluations and instituting appropriate referral system are crucial. Furthermore, establishment of neonatal and pediatric intensive care and pediatric cardiac, cardiac surgery and catheterization laboratory units in the same tertiary center is suggested.


Keywords: Prognosis; Congenital heart disease; Newborn 

Full Text:



Cho SY, Oh JH, Lee JH, Lee JY, Lee SJ, Han JW, et al. Recent incidence of congenital heart disease in neonatal care unit of secondary medical center: a single center study. Korean J Pediatr. 2012;55(7):232-7.

Liu Z, Li X, Li N, Li S, Deng K, Lin Y, et al. Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case-control study. Environ Health. 2013;12:25.

Nikyar B, Sedehi M, Mirfazeli A, Qorbani M, Golalipour MJ. Prevalence and Pattern of Congenital Heart Disease among Neonates in Gorgan, Northern Iran (2007-2008). Iran J Pediatr. 2011;21(3):307-12.

Yun SW. Congenital heart disease in the newborn requiring early intervention. Korean J Pediatr. 2011;54(5):183-191.

Ascher SB, Smith PB, Clark RH, Cohen-Wolkowiez M, Li JS, Watt K, et al. Sepsis in young infants with congenital heart disease. Early Hum Dev. 2012;88 Suppl 2:S92-7.

Racial differences by gestational age in neonatal deaths attributable to congenital heart defects—United States, 2003–2006. MMWR Morb Mortal Wkly Rep. 2010; 59:1208–11.

Boneva RS, Botto LD, Moore CA, Yang Q, Correa A, Erickson JD. Mortality associated with

congenital heart defects in the United States: trends and racial disparities, 1979–1997. Circulation. 2001;103:2376–81.

Wichman CL, Moore KM, Lang TR, St Sauver JL, Heise RH Jr, Watson WJ. Congenital heart disease associated with selective serotonin reuptake inhibitor use during pregnancy. Mayo Clin Proc. 2009;84(1):23-7.

Richards AA, Garg V. Genetics of congenital heart disease. Curr Cardiol Rev. 2010;6(2):91-7.

Wang E, Sun S, Qiao B, Duan W, Huang G, An Y, et al. Identification of functional mutations in GATA4 in patients with congenital heart disease. PLoS One. 2013;8(4):e62138.

Billett J, Majeed A, Gatzoulis M, Cowie M. Trends in hospital admissions, in-hospital case fatality and population mortality from congenital heart disease in England, 1994 to 2004. Heart. 2008;94(3):342-8.

Harris IS. Management of Pregnancy in Patients with Congenital Heart Disease. Prog Cardiovasc Dis. 2011;53(4): 305–311.

Hoffman JI, Christanson R. Congenital heart disease in cohort of 19,502 birth with long – term follow –up. Am J Cardiol. 1978;42: 641 -647.

Kecskes Z, Cartwright D. Poor outcome of very low birthweight babies with serious congenital heart disease. Arch Dis Child Fetal Neonatal Ed. 2002;87(1): F31-F33.

Cheng HH, Almodovar MC, Laussen PC, Wypij D, Polito A, Brown DW, et al. Outcomes and risk factors for mortality in premature neonates with critical congenital heart disease. Pediatr Cardiol. 2011:32(8):1139-1146.

Brown KL, Ridout DA, Hoskote A, Verhulst L, Ricci M, Bull C. Delayed diagnosis of congenital heart disease worsens preoprative condition and outcome of surgery in neonates. Heart. 2006;92:1298-1302.

Haffman JIE, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J, 2004;147, 425 -439.

Anagnostou K, Messenger L, Yates R, Kelsall W. Outcome of infants with prenatally diagnosed congenital heart disease delivered outside specialist paediatric cardiac centres. Arch Dis Child Fetal Neonatal Ed. 2013;98(3):F218-21.

Sawanta SP, Amin AS, Bhat M. Prevalence, pattern and outcome of congenital heart disease in Bhabha Atomic Research Centre Hospital, Mumbai. Indian J pediatr. 2013;80(4):286-291.

Padley JR, Cole AD, Pye VE, Chard RB, Nicholson IA, Jacobe S, et al. Five-year analysis of operative mortality and neonatal outcomes in congenital heart disease. Heart Lung Circ. 2011;20(7):460-7.

Alfieris GM, Dadlani GH, Vermilion RP, Smith FC, Gaum WE, Lipshultz SE, et al. Regional sharing optimizes arterial switch outcomes. Pediatric Cardiology. 2005;20:21-25.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

2013-2023 (CC-BY) Australian International Academic Centre PTY.LTD.

Advances in Bioscience and Clinical Medicine