Is ginger (Zingiber officinale) mouthwash a convenient therapeutic for denture stomatitis?

Hosein Eslami, Solmaz Pakroo, Taher Entezari Maleki, Nazila Sadeghi, Vahid Fakhrzadeh

Abstract


Introduction: Denture stomatitis is the most common type of chronic oral candidiasis. Ginger (Zingiber officinale) is an herbal plant with profound antioxidant, antibacterial, anti-inflammatory and antifungal effects with possible effects on Candida albicans. In this study, we aimed at comparing the efficacy of ginger and nystatin mouthwashes on denture stomatitis.

Materials and Methods: In this randomized clinical trial, 30 patients with type II denture stomatitis were randomly assigned into two groups. Group 1 received ginger mouthwash (20 ml, 3 times a day for 20 days), while group 2 used nystatin mouthwash (500000 IU, 3 times a day for 20 days). The patients were visited on days 5, 10, 15, 20. In each follow-up visit, the length and width of erythema were measured using a digital caliper. Patients’ satisfaction with the treatment was evaluated at the end of the study.

Results: During a 20-day treatment period, both treatments significantly reduced the width and length of the erythema (P<0.001); but the changes between groups were not significant (P=0.9 for both measurements). Patients receiving ginger mouthwash were significantly more satisfied with the outcome compared to those receiving nystatin mouthwash (86.7% vs. 13.3%, P<0.001).

Conclusion: Although both mouthwashes have acceptable efficacy on denture stomatitis, patients were more satisfied with ginger use. Therefore, ginger mouthwash is recommended as an alternative to nystatin mouthwash in treatment of denture stomatitis.

 

Keywords: Denture stomatitis; Ginger; Nystatin; Mouthwash


Full Text:

PDF

References


Al-Dwairi ZN. Prevalence and risk factors associated with denture-related stomatitis in healthy subjects attending a dental teaching hospital in North Jordan. J Ir Dent Assoc. 2008;54(2):80-3.

Salerno C, Pascale M, Contaldo M, Esposito V, Busciolano M, Milillo L, et al. Candida-associated denture stomatitis. Med Oral Patol Oral Cir Bucal. 2011;16:139-43.

Gendreau L, Loewy ZG. Epidemiology and etiology of denture stomatitis. J Prosthodont. 2011;20(4):251-60.

Jean B, Jean PG, Louis de K, Sylvie LA, Benoit L, Pierre R. Reassessing the presence of Candida albicans in denture-related stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:51-59.

Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW. Candida-associated denture stomatitis. Aetiology and management: a review. Part 3. Treatment of oral candidosis. Aust Dent J. 1998;43:244–249.

Bilhan H, Sulun T, Erkose G, Kurt H, Erturan Z, Kutay O, et al. The role of Candida albicans hyphae and Lactobacillus in denture-related stomatitis. Clin Oral Investig. 2009;13(4):363-8.

Iacopino AM, Wathen WF. Oral candidal infection and denture stomatitis: A comprehensive review. J Am Dent Assoc. 1992;123:46-51.

Shay K, Truhlar MR, Renner RP. Oropharyngeal candidosis in the older patient. J Am Geriatr Soc. 1997;45:863-70.

Dorocka-Bobkowska B, Konopka K. Susceptibility of candida isolates from denture-related stomatitis to antifungal agents in vitro. Int J Prosthodont. 2007;20:504-6.

Martinez-Beneyto Y, Lopez-Jornet P, Velandrino-Nicolas A, Jornet-Garcia V. Use of antifungal agents for oral candidiasis: Results of a national survey. Int J Dent Hyg. 2010;8:47-52.

Bissell V, Felix DH, Wray D. Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis. Oral Surg Oral Med Oral Pathol. 1993;76:35-9.

Martin-Mazuelos E, Aller AI, Romero MJ, Rodriguez Armijo A, Gutierrez MJ, Bernal S, et al. Response to Fluconazole and itraconazole of Candida spp. in denture stomatitis. Mycoses. 1997;40:283-9.

Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503-35.

Karyotakis NC, Anaissie EL. The new antifungal azoles: Fluconazole and itraconazole. Curr Opin Infect Dis. 1994;7:658-66.

Salerno C, Pascale M, Contaldo M, Esposito V, Busciolano M, Milillo L, et al. Candida-associated denture stomatitis. Med Oral Patol Oral Cir Bucal. 2011;16:139-43.

Pires FR, Santos EB, Bonan PR, De Almeida OP, Lopes MA. Denture stomatitis and salivary candida in Brazilian edentulous patients. J Oral Rehabil. 2002; 29:1115-9.

Sanita PV, Machado AL, Pavarina AC, Massucato EM, Colombo AL, Vergani CE. Microwave denture disinfection versus nystatin in treating patients with well-controlled type 2 diabetes and denture stomatitis: a randomized clinical trial. Int J Prosthodont. 2012;25(3):232-44.

Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW. Candida-associated denture stomatitis. Aetiology and management: a review. Part 3. Treatment of oral candidosis. Aust Dent J. 1998;43(4):244-9.

Bliddal H, Rosetzsky A, Schlichting P, Weidner MS, Andersen LA, Ibfelt HH, et al. A randomized, placebo controlled, cross-over study of ginger extracts and Ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 2000;8(1):9-12.

Mahady GB, Pendland SL, Yun GS, Lu ZZ, Stoia A. Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. Anticancer Res. 2003;23(5A):3699-702.

Ficker CE, Smith ML, Susiarti S, Leaman DJ, Irawati C, Arnason JT. Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo). J Ethnopharmacol. 2003;85:289-293.

Rahmani AH, Shabrmi FM, Aly SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol Pathophysiol Pharmacol. 2014;6(2):125-36.

Giriraju A, Yunus GY. Assessment of antimicrobial potential of 10% ginger extract against Streptococcus mutans, Candida albicans, and Enterococcus faecalis: an in vitro study. Indian J Dent Res. 2013;24(4):397-400.

Shankland WE 2nd. Four common herbs seen in dental practice: properties and potential adverse effects. Cranio. 2009;27(2):118-24.

Figueiral MH, Azul A, Pinto E, Fonseca PA, Branco FM, Scully C. Denture-related stomatitis: identification of aetiological and predisposing factors - a large cohort. J Oral Rehabil. 2007;34:448-55.

Budtz-Jorgensen E, Bertram U. Denture stomatitis. I. The etiology in relation to trauma and infection. Acta Odontol Scand. 1970;28(1):71-92.

Sabzghabaee A, Shirdare Z, Ebadian B, Aslani A, Ghannadi A. Clinical evaluation of the essential oil of Pelargonium graveolens for the treatment of denture stomatitis. Dent Res J (Isfahan). 2011;8(Suppl 1):S105-8.

Park M, Bae J, Lee D. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res. 2008;22(11):1446-9.

Atai Z, Atapour M, Mohseni M. Inhibitory effect of ginger extract on Candida albicans. Am J Applied Sci. 2009;6:1067-69.

Mohammadi R, Moattar F. Antifungal activity of Zingiber officinale Rosc. essential oil against fluconazole resistant vaginal isolates of Candida albicans. J Med Plants. 2007;6:22-27.

Al-Sumaidae RR. Antifungal action of some natural oils on acrylic resin denture base materials. Al-Rafidain Dent J. 2012;12(2):295-300.

Ellepola AN, Panagoda GJ, Samaranayake LP. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999;14:358-63.

Ellepola AN, Samaranayake LP. Adhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agents. Arch Oral Biol. 1998;12:999-1007.

Blomgren J, Berggren U, Jontell M. Fluconazole versus nystatin in the treatment of oral candidosis. Acta Odontol Scand. 1998;56:202-5.

Chen IN, Chang CC, Ng CC, Wang CY, Shyu YT, Chang TL. Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan. Plant Foods Hum Nutr. 2008;63(1):15-20.

Chairgulprasert V, Prasertsongskun S, Wichaporn W. Chemical constituents of the essential oil and antibacterial activity of Zingiber wrayi var. halabala. Songklanakarin J Sci Technol. 2005;27(4):813-8.


Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

2013-2018 (CC-BY) Australian International Academic Centre PTY.LTD.

Advances in Bioscience and Clinical Medicine